The drug tolerant persisters of Riemerella anatipestifer can be eradicated by a combination of two or three antibiotics.

ABSTRACT:

Background

Riemerella anatipestifer (RA), the causative agent of duck infectious serositis, leads to high mortality in duck flocks and great economic losses in duck industry. Previous studies on RA are largely focused on its detection, virulence factors, serology, epidemiology as well as antibiotic resistance. Neither drug tolerant persisters nor the persister level under the treatment of antibiotics has been revealed. The persisters are non-growing or dormant cells within an isogenic bacterial population; they play important roles in recurrent infection and formation of drug resistant mutants. The aim of this study is to detect the drug tolerant persisters from the exponentially grown population of RA reference strain (RA 11845) or RA clinical isolate (RA TQ3), and address whether

SUBMITTER: Tang T 

PROVIDER: S-EPMC6194556 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature