Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC.

ABSTRACT:

Background

Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC.

Methods

The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein-protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC.

Results

Here, 18

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6194557 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature