Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca²⁺-dependent NF-κB and MAPK pathways.

ABSTRACT:

Background

The extensive biological applications of zinc oxide nanoparticles (ZnO NPs) in stomatology have created serious concerns about their biotoxicity. In our previous study, ZnO NPs were confirmed to transfer to the central nervous system (CNS) via the taste nerve pathway and cause neurodegeneration after 30 days of tongue instillation. However, the potential adverse effects on the brain caused by tongue-instilled ZnO NPs are not fully known.

Methods

In this study, the biodistribution of Zn, cerebral histopathology and inflammatory responses were analysed after 30 days of ZnO NPs tongue instillation. Moreover, the molecular mechanisms underlying neuroinflammation in vivo were further elucidated by treating BV2 and PC12 cells with ZnO NPs in vitro.

Results

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SUBMITTER: Liang H 

PROVIDER: S-EPMC6194560 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature