An African perspective on the genetic risk of chronic kidney disease: a systematic review.

ABSTRACT:

Background

Individuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking.

Methods

We conducted a systematic review to critically evaluate the existing studies on CKD genetic risk inferred by polymorphism(s) amongst African populations in Africa. The study followed the HuGE handbook and PRISMA protocol. We included studies reporting on the association of polymorphism(s) with prevalent CKD, end-stage renaldisease (ESRD) or CKD-associated traits. Given the very few studies investigating the effects of the same single nucleotide polymorphisms (SNPs) on CKD risk, a narrative synthesis of the evidence was conducted.

Results

A total o

SUBMITTER: George C 

PROVIDER: S-EPMC6194564 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature