The antityrosinase and antioxidant activities of flavonoids dominated by the number and location of phenolic hydroxyl groups.

ABSTRACT:

Background

Compounds with the ability to scavenge reactive oxygen species (ROS) and inhibit tyrosinase may be useful for the treatment and prevention from ROS-related diseases. The number and location of phenolic hydroxyl of the flavonoids will significantly influence the inhibition of tyrosinase activity. Phenolic hydroxyl is indispensable to the antioxidant activity of flavonoids. Isoeugenol, shikonin, baicalein, rosmarinic acid, and dihydromyricetin have respectively one, two, three, four, or five phenolic hydroxyls. The different molecular structures with the similar structure to l-3,4-dihydroxyphenylalanine (l-DOPA) were expected to the different antityrosinase and antioxidant activities.

Methods

This investigation tested the antityrosinase activity, the inhibition cons

SUBMITTER: Zuo AR 

PROVIDER: S-EPMC6194685 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature