Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia.

ABSTRACT: Alzheimer's disease (AD) is an irreversible, devastating neurodegenerative brain disorder characterized by the loss of neurons and subsequent cognitive decline. Despite considerable progress in the understanding of the pathophysiology of AD, the precise molecular mechanisms that cause the disease remain elusive. By now, there is ample evidence that activated microglia have a critical role in the initiation and progression of AD. The present study describes the identification of Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel AD-related factor in both transgenic mice and sporadic AD patients by expression profiling, immunohistochemistry and ELISA measurements. We show that GPNMB levels increase in an age-dependent manner in transgenic AD models showing profound cerebral neu

SUBMITTER: Huttenrauch M 

PROVIDER: S-EPMC6194687 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature