Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier.

ABSTRACT: This review considers efflux of substances from brain parenchyma quantified as values of clearances (CL, stated in µL g^-1 min^-1). Total clearance of a substance is the sum of clearance values for all available routes including perivascular pathways and the blood-brain barrier. Perivascular efflux contributes to the clearance of all water-soluble substances. Substances leaving via the perivascular routes may enter cerebrospinal fluid (CSF) or lymph. These routes are also involved in entry to the parenchyma from CSF. However, evidence demonstrating net fluid flow inwards along arteries and then outwards along veins (the glymphatic hypothesis) is still lacking. CL_perivascular, that via perivascular routes, has been measured by following the fate of exogenously

SUBMITTER: Hladky SB 

PROVIDER: S-EPMC6194691 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature