Subcellular organization of UBE3A in human cerebral cortex.

ABSTRACT:

Background

Loss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its cellular and subcellular organization in the human brain. The issue is important, since UBE3A's localization is integral to its function.

Methods

We used light and electron microscopic immunohistochemistry to study the cellular and subcellular distribution of UBE3A in the adult human cerebral cortex. Experiments were performed on multiple tissue sources, but our results focused on optimally preserved material, using surgically resected human temporal cortex of high ultrastructural quality from nine individuals.

Results

W

SUBMITTER: Burette AC 

PROVIDER: S-EPMC6194692 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature