Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma.

ABSTRACT:

Background

Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients.

Methods

The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL patients from 2006 to 2017. The log-rank test, univariate analysis, and Cox regression analysis were applied to evaluate the relationship between ESR and survival. An ESR of more than 37.5 mm/hour was found to be the optimal threshold value for predicting prognosis.

Results

ESR was associated with more frequent advanced Ann Arbor stage, poorer performance status, elevated lactate dehydrogenase level, the presence of B symptoms, high-risk International Progn

SUBMITTER: Wu S 

PROVIDER: S-EPMC6194702 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature