Untargeted lipidomic features associated with colorectal cancer in a prospective cohort.

ABSTRACT:

Background

Epidemiologists are beginning to employ metabolomics and lipidomics with archived blood from incident cases and controls to discover causes of cancer. Although several such studies have focused on colorectal cancer (CRC), they all followed targeted or semi-targeted designs that limited their ability to find discriminating molecules and pathways related to the causes of CRC.

Methods

Using an untargeted design, we measured lipophilic metabolites in prediagnostic serum from 66 CRC patients and 66 matched controls from the European Prospective Investigation into Cancer and Nutrition (Turin, Italy). Samples were analyzed by liquid chromatography-high-resolution mass spectrometry (LC-MS), resulting in 8690 features for statistical analysis.

Results

Rather than th

SUBMITTER: Perttula K 

PROVIDER: S-EPMC6194742 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature