Selective C-H halogenation over hydroxylation by non-heme iron(iv)-oxo.

ABSTRACT: Non-heme iron based halogenase enzymes promote selective halogenation of the sp³-C-H bond through iron(iv)-oxo-halide active species. During halogenation, competitive hydroxylation can be prevented completely in enzymatic systems. However, synthetic iron(iv)-oxo-halide intermediates often result in a mixture of halogenation and hydroxylation products. In this report, we have developed a new synthetic strategy by employing non-heme iron based complexes for selective sp³-C-H halogenation by overriding hydroxylation. A room temperature stable, iron(iv)-oxo complex, [Fe(2PyN2Q)(O)]²⁺ was directed for hydrogen atom abstraction (HAA) from aliphatic substrates and the iron(ii)-halide [Fe^II(2PyN2Q)(X)]⁺ (X, halogen) was exploited in conjunctio

SUBMITTER: Rana S 

PROVIDER: S-EPMC6194801 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature