Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression.

ABSTRACT:

Context

Although important advances have been made in understanding the genetics of endocrine tumors, cellular physiology is relatively understudied as a determinant of tumor behavior. Oxidative stress and reactive oxygen species are metabolic factors that may affect tumor behavior, and these are, in part, controlled by manganese-dependent superoxide dismutase (MnSod), the mitochondrial superoxide dismutase (encoded by SOD2).

Objective

We sought to understand the role of MnSod in the prognosis of aggressive human endocrine cancers and directly assessed the effect of MnSod under- or overexpression on tumor behavior, using established mouse thyroid cancer models.

Methods

We performed transcriptome analysis of human and mouse models of endocrine cancer. To address the ro

SUBMITTER: Ashtekar A 

PROVIDER: S-EPMC6194813 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature