Adipose Tissue Transferrin and Insulin Resistance.

ABSTRACT:

Context

Excessive body iron stores are a risk factor for decreased insulin sensitivity (SI) and diabetes. We hypothesized that transcriptional dysregulation of genes involved in iron metabolism in adipocytes causes insulin resistance.

Objective and design

To define the genetic regulation of iron metabolism and its role in SI, we used gene expression, genotype, and SI data from an African American cohort (N = 256). Replication studies were performed in independent European ancestry cohorts. In vitro studies in human adipocytes were performed to define the role of a selected gene in causing insulin resistance.

Results

Among 62 transcripts representing iron homeostasis genes, expression of 30 in adipose tissue were correlated with SI. Transferrin (TF) and ferritin heavy

SUBMITTER: McClain DA 

PROVIDER: S-EPMC6194856 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature