Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction.

ABSTRACT: Chronic inflammation is associated with a variety of pathological conditions in epithelial tissues, including cancer, metaplasia and aberrant wound healing. In relation to this, a significant body of evidence suggests that aberration of epithelial stem and progenitor cell function is a contributing factor in inflammation-related disease, although the underlying cellular and molecular mechanisms remain to be fully elucidated. In this study, we have delineated the effect of chronic inflammation on epithelial stem/progenitor cells using the corneal epithelium as a model tissue. Using a combination of mouse genetics, pharmacological approaches and in vitro assays, we demonstrate that chronic inflammation elicits aberrant mechanotransduction in the regenerating corneal epithelium. As a conseque

SUBMITTER: Nowell CS 

PROVIDER: S-EPMC6195194 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature