Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin.

ABSTRACT: The extent to which early events shape tumor evolution is largely uncharacterized, even though a better understanding of these early events may help identify key vulnerabilities in advanced tumors. Here, using genetically defined mouse models of small cell lung cancer (SCLC), we uncovered distinct metastatic programs attributable to the cell type of origin. In one model, tumors gain metastatic ability through amplification of the transcription factor NFIB and a widespread increase in chromatin accessibility, whereas in the other model, tumors become metastatic in the absence of NFIB-driven chromatin alterations. Gene-expression and chromatin accessibility analyses identify distinct mechanisms as well as markers predictive of metastatic progression in both groups. Underlying the difference

SUBMITTER: Yang D 

PROVIDER: S-EPMC6195211 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature