The relationship between resting energy expenditure and thyroid hormones in response to short-term weight loss in severe obesity.

ABSTRACT:

Background

Regulating thermogenesis is a major task of thyroid hormones (THs), and involves TH-responsive energetic processes at the central and peripheral level. In severe obesity, little is known on the relationship between THs and resting energy expenditure (REE) before and after weight loss.

Methods

We enrolled 100 euthyroid subjects with severe obesity who were equally distributed between genders. Each was examined before and after completion of a 4-wk inpatient multidisciplinary dieting program and subjected to measurement of thyroid function, REE, fat-free mass (FFM, kg) and percent fat mass (FM).

Results

Baseline REE was lower than predicted in 70 obese patients, and overall associated with BMI, FFM and FM but not thyroid-related parameters. By the study end,

SUBMITTER: Marzullo P 

PROVIDER: S-EPMC6195261 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature