Functional regeneration of tendons using scaffolds with physical anisotropy engineered via microarchitectural manipulation.

ABSTRACT: Structural and hierarchical anisotropy underlies the structure-function relationship of most living tissues. Attempts to exploit the interplay between cells and their immediate environment have rarely featured macroscale, three-dimensional constructs required for clinical applications. Furthermore, compromises to biomechanical robustness during fabrication often limit the scaffold's relevance in translational medicine. We report a polymeric three-dimensional scaffold with tendon-like mechanical properties and controlled anisotropic microstructures. The scaffold was composed of two distinct portions, which enabled high porosity while retaining tendon-like mechanical properties. When tenocytes were cultured in vitro on the scaffold, phenotypic markers of tenogenesis such as type-I collagen,

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6195336 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature