Phenotypic and Functional Signatures of Herpes Simplex Virus-Specific Effector Memory CD73⁺CD45RA^highCCR7^lowCD8⁺ T_EMRA and CD73⁺CD45RA^lowCCR7^lowCD8⁺ T_EM Cells Are Associated with Asymptomatic Ocular Herpes.

ABSTRACT: HSV type 1 (HSV-1)-specific CD8⁺ T cells protect from herpes infection and disease. However, the nature of protective CD8⁺ T cells in HSV-1 seropositive healthy asymptomatic (ASYMP) individuals (with no history of clinical herpes disease) remains to be determined. In this study, we compared the phenotype and function of HSV-specific CD8⁺ T cells from HLA-A*02:01-positive ASYMP and symptomatic (SYMP) individuals (with a documented history of numerous episodes of recurrent ocular herpetic disease). We report that although SYMP and ASYMP individuals have similar frequencies of HSV-specific CD8⁺ T cells, the "naturally" protected ASYMP individuals have a significantly higher proportion of multifunctional HSV-specific effector memory CD8⁺ T

SUBMITTER: Srivastava R 

PROVIDER: S-EPMC6195422 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature