Frontline Science: PECAM-1 (CD31) expression in naive and memory, but not acutely activated, CD8⁺ T cells.

ABSTRACT: Inhibitory cell surface proteins on T cells are often dynamically regulated, which contributes to their physiologic function. PECAM-1 (CD31) is an inhibitory receptor that facilitates TGF-β-mediated suppression of T cell activity. It is well established in CD4⁺ T cells that PECAM-1 is expressed in naïve recent thymic emigrants, but is down-regulated after acute T cell activation and absent from memory cells. The extent to which PECAM-1 expression is similarly regulated in CD8⁺ T cells is much less well characterized. We evaluated T cells recovered from mice after infection with a model intracellular pathogen and determined that, in CD8⁺ T cells, PECAM-1 expression was strongly down-regulated during acute infection but re-expressed to intermediate levels in

SUBMITTER: Newman DK 

PROVIDER: S-EPMC6195461 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature