Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells.

ABSTRACT: A variety of environmental agents has been found to influence the development of autoimmune diseases; in particular, the studies investigating the potential association of systemic autoimmune rheumatic diseases with environmental micro and nano-particulate matter are very few and contradictory. In this study, the role of diesel exhaust particles (DEPs), one of the most important components of environment particulate matter, emitted from Euro 4 and Euro 5 engines in altering the Normal Human Bronchial Epithelial (NHBE) cell biological activity was evaluated. NHBE cells were exposed in vitro to Euro 4 and Euro 5 particle carbon core, sampled upstream of the typical emission after-treatment systems (diesel oxidation catalyst and diesel particulate filter), whose surfaces have been washed from

SUBMITTER: Colasanti T 

PROVIDER: S-EPMC6195610 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature