Early effects of exposure-based cognitive behaviour therapy on the neural correlates of anxiety.

ABSTRACT: Exposure-based cognitive-behaviour therapy (CBT) for anxiety disorders is an effective intervention, but the brain mechanisms driving recovery are largely unknown. In this experimental medicine study, we investigated to what degree CBT affects neural markers of anxiety at an early stage of treatment, to identify dynamic mechanistic changes which might be crucial in the process of recovery as opposed to those seen following full treatment completion. In a randomised controlled trial, unmedicated patients with panic disorder either received four weekly sessions of exposure-based CBT (N = 14) or were allocated to a waiting group (N = 14). Symptom severity was measured before and after the intervention. During functional magnetic resonance imaging (fMRI), patients performed an emotion regulati

SUBMITTER: Reinecke A 

PROVIDER: S-EPMC6195621 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature