Implicit time-place conditioning alters Per2 mRNA expression selectively in striatum without shifting its circadian clocks.

ABSTRACT: Animals create implicit memories of the time of day that significant events occur then anticipate the recurrence of those conditions at the same time on subsequent days. We tested the hypothesis that implicit time memory for daily encounters relies on the setting of the canonical circadian clockwork in brain areas involved in the formation or expression of context memories. We conditioned mice to avoid locations paired with a mild foot shock at one of two Zeitgeber times set 8 hours apart. Place avoidance was exhibited only when testing time matched the prior training time. The suprachiasmatic nucleus, dorsal striatum, nucleus accumbens, cingulate cortex, hippocampal complex, and amygdala were assessed for clock gene expression. Baseline phase dependent differences in clock gene expression

SUBMITTER: Shrestha TC 

PROVIDER: S-EPMC6195625 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature