New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.

ABSTRACT:

Background

Bacterial meningitis remains a big threat to the integrity of the central nervous system (CNS), despite the advancements in antimicrobial reagents. Escherichia coli is a bacterial pathogen that can disrupt the CNS function, especially in neonates. E. coli meningitis occurs after bacteria invade the brain microvascular endothelial cells (BMECs) that form a direct and essential barrier restricting the entry of circulating microbes and toxins to the brain. Previous studies have reported on several cellular proteins that function during meningitic E. coli infections; however, more comprehensive investigations to elucidate the potential targets involved in E. coli meningitis are essential to better understand this disease and discover new treatments for it.

Methods

The

SUBMITTER: Liu WT 

PROVIDER: S-EPMC6195690 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature