Association of COL9A3 trp3 polymorphism with intervertebral disk degeneration: a meta-analysis.

ABSTRACT:

Background

Intervertebral disk degeneration (IDD) is a common musculoskeletal disease associated with genetic factors. COL9A3 gene encodes the α3 (IX) chain of type IX collagen that is part of the interior structure of the disc. Mutations in COL9A3 gene sequence, leading to an Arg103Trp substitution in its 3 chain (the Trp3 allele at rs61734651 site), respectively, have been found to be connected with IDD occurrence in several studies. However, those studies have showed conflict results. Thus, a meta-analysis has been performed to assess the associations between the COL9A3 trp3 polymorphism and IDD.

Methods

Data were gathered from the following four electronic databases: PubMed, Web of Science (WOS), Embase and Cochrane library up to January 01, 2018. The pooled odds ratio (

SUBMITTER: Huang D 

PROVIDER: S-EPMC6195691 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature