Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial.

ABSTRACT:

Background

Cytokines are critical to human disease and are attractive therapeutic targets given their widespread influence on gene regulation and transcription. Defining the downstream regulatory mechanisms influenced by cytokines is central to defining drug and disease mechanisms. One promising strategy is to use interactions between expression quantitative trait loci (eQTLs) and cytokine levels to define target genes and mechanisms.

Results

In a clinical trial for anti-IL-6 in patients with systemic lupus erythematosus, we measure interferon (IFN) status, anti-IL-6 drug exposure, and whole blood genome-wide gene expression at three time points. We show that repeat transcriptomic measurements increases the number of cis eQTLs identified compared to using a single time point

SUBMITTER: Davenport EE 

PROVIDER: S-EPMC6195724 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature