T cell activation and cardiovascular risk in type 2 diabetes mellitus: a protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

The burden of non-communicable diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs) has drastically increased in developing countries over the years. Although recent evidence points to chronic immune activation to be a significant aspect in the pathogenesis and development of T2DM and CVDs, the exact role of T cells is not fully understood. Therefore, we aim to investigate T cell function and cardio vascular risk in T2DM. In addition, the therapeutic effect of blood glucose-lowering drugs to reverse hyperglycaemia induced T cell dysfunction and myocardial infarction will be reviewed.

Methods

This will be a systematic review and meta-analysis of published studies assessing T cell activation and cardiovascular risk in adults with T2D

SUBMITTER: Nyambuya TM 

PROVIDER: S-EPMC6195734 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature