Glycan binding patterns of human rotavirus P[10] VP8* protein.

ABSTRACT:

Background

Rotaviruses (RVs) are a major cause of acute children gastroenteritis. The rotavirus P [10] belongs to P[I] genogroup of group A rotaviruses that mainly infect animals, while the rotavirus P [10] was mainly identified from human infection. The rotavirus P [10] is an unusual genotype and the recognition pattern of cellular receptors remains unclear.

Methods

We expressed and purified the RV P [10] VP8* protein and investigated the saliva and oligosaccharide binding profiles of the protein. A homology model of the P [10] VP8* core protein was built and the superimposition structural analysis of P [10] VP8* protein on P [19] VP8* in complex with mucin core 2 was performed to explore the possible docking structural basis of P [10] VP8* and mucin cores.

Results

O

SUBMITTER: Pang LL 

PROVIDER: S-EPMC6195756 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature