Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin.

ABSTRACT: The rise of widespread antifungal resistance fuels the need to explore new classes of inhibitory molecules as potential novel inhibitors. Recently a plant natural product poacic acid (PA) was shown to inhibit β-1,3-glucan synthesis, and to have antifungal activity against a range of plant pathogens and against Saccharomyces cerevisiae. As with the echinocandins, such as caspofungin, PA targets the synthesis of cell wall β-1,3-glucan and has potential utility in the treatment of medically important fungi. However, the antifungal activity of PA against human pathogenic Candida species has not been explored and the precise mode of action of this compound is not understood. Here, we show that PA sensitivity is regulated by the calcineurin pathway and that susceptibility to PA var

SUBMITTER: Lee KK 

PROVIDER: S-EPMC6195761 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature