Discovery of (Dihydro)pyrazine N-Oxides via Genome Mining in Pseudomonas.

ABSTRACT: Overexpression of the Pseudomonas virulence factor ( pvf) biosynthetic operon led to the identification of a family of pyrazine N-oxides (PNOs), including a novel dihydropyrazine N,N'-dioxide (dPNO) metabolite. The nonribosomal peptide synthetase responsible for production of (d)PNOs was characterized, and a biosynthetic pathway for (d)PNOs was proposed. This work highlights the unique chemistry catalyzed by pvf-encoded enzymes and sets the stage for bioactivity studies of the metabolites produced by the virulence pathway.

SUBMITTER: Kretsch AM 

PROVIDER: S-EPMC6195765 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature