Aquaporin-3 mediates ovarian steroid hormone-induced motility of endometrial epithelial cells.

ABSTRACT:

Study question

How does aquaporin-3 (AQP3) affect endometrial receptivity?

Summary answer

AQP3, which is regulated by the combination and estrogen (E2) and progesterone (P4), induces epithelial-mesenchymal transition (EMT) of endometrial epithelial cells.

What is known already

Embryo implantation is an extremely complex process, and endometrial receptivity is essential for successful embryo implantation. Estrogen and progesterone regulate endometrial receptivity. AQP3, which is regulated by estrogen (E2), increases cell migration and invasion ability by regulating the expression of EMT-related factors and influencing the reorganization of the actin cytoskeleton.

Study design, size, duration

This study investigated the pathophysiological significance of AQP3 in

SUBMITTER: Cui D 

PROVIDER: S-EPMC6195804 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature