Brain circuit dysfunction in a distinct subset of chronic psychotic patients.

ABSTRACT:

Objective

To identify the mechanism of unexplained hyponatremia and primary polydipsia in schizophrenia and its relationship to the underlying psychiatric illness.

Methods

Briefly review previous studies that led to the conclusion the hyponatremia reflects altered hippocampal inhibition of peripheral neuroendocrine secretion. In greater detail, present the evidence supporting the hypothesis that circuit dysfunction associated with the hyponatremia and the polydipsia contributes to the underlying mental disorder.

Results

Polydipsic patients with and without hyponatremia exhibit enhanced neuroendocrine responses to psychological stress in proportion to structural deformations on their anterior hippocampus, amygdala and anterior hypothalamus. Nonpolydipsic patients exhib

SUBMITTER: Goldman MB 

PROVIDER: S-EPMC6195810 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature