Sleep-disordered breathing, circulating exosomes, and insulin sensitivity in adipocytes.

ABSTRACT:

Background

Sleep-disordered-breathing (SDB), which is characterized by chronic intermittent hypoxia (IH) and sleep fragmentation (SF), is a prevalent condition that promotes metabolic dysfunction, particularly among patients suffering from obstructive hypoventilation syndrome (OHS). Exosomes are generated ubiquitously, are readily present in the circulation, and their cargo may exert substantial functional cellular alterations in both physiological and pathological conditions. However, the effects of plasma exosomes on adipocyte metabolism in patients with OHS or in mice subjected to IH or SF mimicking SDB are unclear.

Methods

Exosomes from fasting morning plasma samples from obese adults with polysomnographically-confirmed OSA before and after 3 months of adherent CPAP ther

SUBMITTER: Khalyfa A 

PROVIDER: S-EPMC6195831 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature