Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.

ABSTRACT:

Background/objectives

Physical activity (PA) protects against a wide range of diseases. Habitual PA appears to be heritable, motivating the search for specific genetic variants that may inform efforts to promote PA and target the best type of PA for each individual.

Subjects/methods

We used data from the UK Biobank to perform the largest genome-wide association study of PA to date, using three measures based on self-report (n_max = 377,234) and two measures based on wrist-worn accelerometry data (n_max = 91,084). We examined genetic correlations of PA with other traits and diseases, as well as tissue-specific gene expression patterns. With data from the Atherosclerosis Risk in Communities (ARIC; n = 8,556) study, we performed a meta-analysis of our top hi

SUBMITTER: Klimentidis YC 

PROVIDER: S-EPMC6195860 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature