Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health.

ABSTRACT:

Background

Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic health, remains unclear.

Methods

We investigated smoking-associated DNA methylation and gene expression variation in adipose tissue biopsies from 542 healthy female twins. Replication, tissue specificity, and longitudinal stability of the smoking-associated effects were explored in additional adipose, blood, skin, and lung samples. We characterized the impact of adipose tissue smoking methylation and expression signals on metabolic disease risk phenotypes, includi

SUBMITTER: Tsai PC 

PROVIDER: S-EPMC6196025 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature