Evaluation of zero-echo-time attenuation correction for integrated PET/MR brain imaging-comparison to head atlas and ⁶⁸Ge-transmission-based attenuation correction.

ABSTRACT:

Background

MRI does not offer a direct method to obtain attenuation correction maps as its predecessors (stand-alone PET and PET/CT), and bone visualisation is particularly challenging. Recently, zero-echo-time (ZTE) was suggested for MR-based attenuation correction (AC). The aim of this work was to evaluate ZTE- and atlas-AC by comparison to ⁶⁸Ge-transmission scan-based AC. Nine patients underwent brain PET/MR and stand-alone PET scanning using the dopamine transporter ligand ¹¹C-PE2I. For each of them, two AC maps were obtained from the MR images: an atlas-based, obtained from T1-weighted LAVA-FLEX imaging with cortical bone inserted using a CT-based atlas, and an AC map generated from proton-density-weighted ZTE images. Stand-alone PET ⁶⁸Ge-trans

SUBMITTER: Sousa JM 

PROVIDER: S-EPMC6196145 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature