New miRNA Signature Heralds Human NK Cell Subsets at Different Maturation Steps: Involvement of miR-146a-5p in the Regulation of KIR Expression.

ABSTRACT: Natural killer cells are cytotoxic innate lymphoid cells that play an important role for early host defenses against infectious pathogens and surveillance against tumor. In humans, NK cells may be divided in various subsets on the basis of the relative CD56 expression and of the low-affinity FcγRIIIA CD16. In particular, the two main NK cell subsets are represented by the CD56^bright/CD16^-/dim and the CD56^dim/CD16^bright NK cells. Experimental evidences indicate that CD56^bright and CD56^dim NK cells represent different maturative stages of the NK cell developmental pathway. We identified multiple miRNAs differentially expressed in CD56^bright/CD16^- and CD56^dim/CD16^bright NK cells using

SUBMITTER: Pesce S 

PROVIDER: S-EPMC6196268 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature