Helicobacter pylori seropositivity and its association with incident all-cause and Alzheimer's disease dementia in large national surveys.

ABSTRACT:

Introduction

Infectious agents were recently implicated in Alzheimer's disease (AD) and etiology of other dementias, notably Helicobacter pylori.

Methods

We tested associations of H. pylori seropositivity with incident all-cause and AD dementia and with AD-related mortality among US adults in a retrospective cohort study. Data from the National Health and Nutrition Surveys III, phase 1 (1988-1991) and 1999-2000 linked with Medicare and National Death Index registries, were used (baseline age ≥45 y, follow-up to 2013, N_pooled = 5927).

Results

A positive association between H. pylori seropositivity and AD mortality was found in men (hazard ratio_{adj, pooled} = 4.33, 95% confidence interval: 1.51-12.41, P = .006), which was replicated for incident AD

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC6196325 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature