3'-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease.

ABSTRACT: The blockade of the HIV protease has become a major target in the search for an effective therapy for AIDS.¹ While many reports of potent HIV-1 inhibitors have appeared recently, the compound Ro 31-8959 remains the least selective for the HIV-1 and HIV-2 proteases.² This property may result in reduced susceptibility to resistance since these represent the genetically most divergent strains of HIV presently known to exist.

SUBMITTER: Thompson WJ 

PROVIDER: S-EPMC6196357 | biostudies-literature | 1993 Jan

REPOSITORIES: biostudies-literature