SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population.

ABSTRACT:

Background

The aim of the study was to explore the association between the SIRT1 single nucleotide polymorphism (SNP) rs3758391 and diffuse large B cell lymphoma (DLBCL) in a Chinese Han population.

Methods

206 patients diagnosed with DLBCL and 219 healthy individuals were recruited in the present study. The genotyping of SIRT1 rs3758391 polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism. The SIRT1 mRNA expression was detected by the Taqman real-time quantitative PCR.

Results

Our study showed that the genotype TT and allele T frequency were significantly higher in DLBCL patients than that of controls (p = 0.02 and 0.01, respectively). No statistical differences were observed between SIRT1 rs3758391 and clinical characterist

SUBMITTER: Kan Y 

PROVIDER: S-EPMC6196412 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature