Aberrant functional connectivity network in subjective memory complaint individuals relates to pathological biomarkers.

ABSTRACT:

Background

Individuals with subjective memory complaints (SMC) feature a higher risk of cognitive decline and clinical progression of Alzheimer's disease (AD). However, the pathological mechanism underlying SMC remains unclear. We aimed to assess the intrinsic connectivity network and its relationship with AD-related pathologies in SMC individuals.

Methods

We included 44 SMC individuals and 40 normal controls who underwent both resting-state functional MRI and positron emission tomography (PET). Based on graph theory approaches, we detected local and global functional connectivity across the whole brain by using degree centrality (DC) and eigenvector centrality (EC) respectively. Additionally, we analyzed amyloid deposition and tauopathy via florbetapir-PET imaging and cereb

SUBMITTER: Li K 

PROVIDER: S-EPMC6196458 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature