Proinsulin C-peptide is an autoantigen in people with type 1 diabetes.

ABSTRACT: Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells, found within the islets of Langerhans in the pancreas, are destroyed by islet-infiltrating T cells. Identifying the antigenic targets of beta-cell reactive T cells is critical to gain insight into the pathogenesis of T1D and develop antigen-specific immunotherapies. Several lines of evidence indicate that insulin is an important target of T cells in T1D. Because many human islet-infiltrating CD4⁺ T cells recognize C-peptide-derived epitopes, we hypothesized that full-length C-peptide (PI_33-63), the peptide excised from proinsulin as it is converted to insulin, is a target of CD4⁺ T cells in people with T1D. CD4⁺ T cell responses to full-length C-peptide were det

SUBMITTER: So M 

PROVIDER: S-EPMC6196477 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature