CXCR6⁺ST2⁺ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth.

ABSTRACT: Memory T helper (mTh) cells play important roles in the reinfection of pathogens and drive the pathogenesis of diseases. While recent studies have characterized the pathogenic mTh2 cell subpopulations driving allergic inflammation, those that induce immune responses against helminth infection remain unknown. We found that IL-5-producing CXCR6⁺ST2⁺CD44⁺ mTh2 cells play a crucial role in the IL-33-dependent inhibition of the fecundity of helminth, whereas other ST2^- mTh2 cells do not. Although both cell types induced the infiltration of granulocytes, especially eosinophils, into the lungs in response to helminth infection, the ST2⁺ mTh2 cell-induced eosinophils expressed higher levels of major basic protein (MBP), which is important for

SUBMITTER: Obata-Ninomiya K 

PROVIDER: S-EPMC6196506 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature