Notch2-dependent DC2s mediate splenic germinal center responses.

ABSTRACT: CD4⁺ T follicular helper (T_FH) cells support germinal center (GC) reactions promoting humoral immunity. Dendritic cell (DC) diversification into genetically distinct subsets allows for specialization in promoting responses against several types of pathogens. Whether any classical DC (cDC) subset is required for humoral immunity is unknown, however. We tested several genetic models that selectively ablate distinct DC subsets in mice for their impact on splenic GC reactions. We identified a requirement for Notch2-dependent cDC2s, but not Batf3-dependent cDC1s or Klf4-dependent cDC2s, in promoting T_FH and GC B cell formation in response to sheep red blood cells and inactivated Listeria monocytogenes This effect was mediated independ

SUBMITTER: Briseno CG 

PROVIDER: S-EPMC6196531 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature