Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells.

ABSTRACT: The ability of cells to collectively interpret surrounding environmental signals underpins their capacity to coordinate their migration in various contexts, including embryonic development and cancer metastasis. One tractable model for studying collective migration is the parapineal, a left-sided group of neurons that arises from bilaterally positioned precursors that undergo a collective migration to the left side of the brain. In zebrafish, the migration of these cells requires Fgf8 and, in this study, we resolve how FGF signaling correlates with-and impacts the migratory dynamics of-the parapineal cell collective. The temporal and spatial dynamics of an FGF reporter transgene reveal that FGF signaling is activated in only few parapineal cells usually located at the leading edge of the p

SUBMITTER: Roussigne M 

PROVIDER: S-EPMC6196547 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature