Assessment of brain-derived neurotrophic factor and osteopontin in a healthy pediatric population.

ABSTRACT: Biomarkers are routinely used for noninvasive identification or monitoring of disease processes in clinical practice, as well as surrogate end points for drug development. There is a significant lack of data regarding biomarkers in children. An understanding of biomarker levels in a healthy pediatric cohort is essential as more studies begin to apply noninvasive biomarkers to pediatric populations. Brain-derived neurotrophic factor (BDNF) functions in neuronal survival and plasticity and is associated with exercise capacity and inflammatory disease processes. Osteopontin (OPN) plays a regulatory role in inflammation and may be a clinically useful biomarker of cardiovascular disease processes, ventricular remodeling, and skeletal muscle regeneration. This study describes our initial experie

SUBMITTER: Chew JD 

PROVIDER: S-EPMC6196610 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature