Vitamin C supplementation in the critically ill: A systematic review and meta-analysis.

ABSTRACT:

Background

Low plasma levels of vitamin C are associated with adverse outcomes, including increased mortality, in critically ill patients. Several trials have suggested that the administration of intravenous vitamin C in this setting may have beneficial effects, such as reducing the incidence of organ failure and improving survival. However, these studies have generally involved combination therapies consisting of vitamin C along with other antioxidants, confounding the effects of vitamin C alone. The primary objective of this meta-analysis is to investigate the effects of isolated intravenous supplementation of vitamin C in adults with critical illness.

Methods

A database search was conducted for studies on the use of intravenous vitamin C in adult patients with critical il

SUBMITTER: Zhang M 

PROVIDER: S-EPMC6196621 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature