Assessment of proximal and peripheral airway dysfunction by computed tomography and respiratory impedance in asthma and COPD patients with fixed airflow obstruction.

ABSTRACT:

Objective

To ascertain: (i) if elderly patients with fixed airflow obstruction (FAO) due to asthma and chronic obstructive pulmonary disease (COPD) have distinct airway morphologic and physiologic changes; (ii) the correlation between the morphology of proximal/peripheral airways and respiratory impedance.

Methods

Twenty-five asthma cases with FAO and 22 COPD patients were enrolled. High-resolution computed tomography was used to measure the wall area (WA) and lumen area (LA) of the proximal airway at the apical segmental bronchus of the right upper lobe (RB1) adjusted by body surface area (BSA) and bronchial wall thickening (BWT _r ) of the peripheral airways and extent of expiratory air trapping (AT _exp ). Respiratory impedance included r

SUBMITTER: Pornsuriyasak P 

PROVIDER: S-EPMC6196666 | biostudies-literature | 2018 Oct-Dec

REPOSITORIES: biostudies-literature