Prenatal nitrate air pollution exposure and reduced child lung function: Timing and fetal sex effects.

ABSTRACT:

Background

Prenatal particulate air pollution exposure may alter lung growth and development in utero in a time-sensitive and sex-specific manner, resulting in reduced lung function in childhood. Such relationships have not been examined for nitrate (NO₃^-).

Methods

We implemented Bayesian distributed lag interaction models (BDLIMs) to identify sensitive prenatal windows for the influence of NO₃^- on lung function at age 7 years, assessing effect modification by fetal sex. Analyses included 191 mother-child dyads. Daily ambient NO₃^- exposure over pregnancy was estimated using a hybrid chemical transport (Geos-Chem)/land-use regression model. Spirometry was performed at mean (SD) age of 6.99 (0.89) years, with fo

SUBMITTER: Bose S 

PROVIDER: S-EPMC6196719 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature