Comparative efficacy of treatment strategies for hepatocellular carcinoma: systematic review and network meta-analysis.

ABSTRACT:

Objective

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. We conducted network meta-regression within a Bayesian framework to compare and rank different treatment strategies for HCC through direct and indirect evidence from international studies.

Methods and analyses

We pooled the OR for 1-year, 3-year and 5-year overall survival, based on lesions of size ˂ 3 cm, 3-5 cm and ≤5 cm, using five therapeutic options including resection (RES), radiofrequency ablation (RFA), microwave ablation (MWA), transcatheter arterial chemoembolisation (TACE) plus RFA (TR) and percutaneous ethanol injection (PEI).

Results

We identified 74 studies, including 26 944 patients. After adjustment for study design, and in the full sample of studies, the tre

SUBMITTER: Tian G 

PROVIDER: S-EPMC6196801 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature