Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes.

ABSTRACT:

Objective

We examined the association of urine complement proteins with progression to end-stage renal disease (ESRD) or death in people with type 2 diabetes and proteinuric diabetic kidney disease (DKD).

Research design and methods

Using targeted mass spectrometry, we quantified urinary abundance of 12 complement proteins in a predominantly Mexican American cohort with type 2 diabetes and proteinuric DKD (n = 141). The association of urine complement proteins with progression to ESRD or death was evaluated using time-to-event analyses.

Results

At baseline, median estimated glomerular filtration rate (eGFR) was 54 mL/min/1.73 m² and urine protein-to-creatinine ratio 2.6 g/g. Sixty-seven participants developed ESRD or died, of whom 39 progressed to ES

SUBMITTER: Vaisar T 

PROVIDER: S-EPMC6196831 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature